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SKIN, HAIR & COSMETICS
Melanotan II
Buy Melanotan II (MT-II): in the literature it centres on pigment formation. Modelled on the body's own hormone α-MSH. 10 mg vial, ≧99% pure.
4.5/5on Trustpilot· Verified reviews
Ordered before 17:00, shipped todayOrder now, shipped Monday
Order todayNow
ShippingMonday 16 Nov.
Expected deliveryTuesday 17 Nov.
Carefully packagedTrack & TraceShipped from the EU
4.5/5on Trustpilot · Verified reviews
Why choose Melanotan II?
- Cyclic peptide of seven amino acids, derived from α-MSH
- 10 mg vial
- Purity ≧99%, supplied as freeze-dried powder
- With every peptide product, you receive 3 ml of bacteriostatic water for free.
- Carefully packaged, shipped from our EU warehouse. Ordered before 17:00, shipped today.
Product information
What is Melanotan II (MT-2)?
Melanotan II, also written as melanotan 2 or MT-II, is a synthetic peptide of seven amino acids. It is derived from α-MSH (alpha-melanocyte-stimulating hormone), an endogenous hormone of the melanocortin family, and is built from the section of that hormone running from amino acid four to ten.
The peptide was developed at the University of Arizona in the late 1980s, as part of a research programme into more stable variants of α-MSH. Melanotan II is not registered as a medicine anywhere.
| Name | Melanotan II |
|---|---|
| Also known as | MT-II, MT-2, Melanotan-II, CHEMBL430239 |
| CAS number | 121062-08-6 |
| Molecular formula | C50H69N15O9 |
| Molecular weight | 1024.2 g/mol |
| Number of amino acids | 7 |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Available vials | 10 mg |
| Purity | ≧99% |
| Form | Lyophilisate (freeze-dried powder) |
| Appearance | White to off-white powder |
| Solvent | Bacteriostatic water |
| Unopened storage | Store at 2–8 °C, in a dry and dark place. |
| Long-term storage | -20 °C, only in powder form |
| After reconstitution | Keep refrigerated at 2–8 °C. Quality declines after approximately 30 days. |
| Use | For laboratory research only |
Why a cyclic peptide?
Natural α-MSH is a linear chain that is broken down in the body within a few minutes. In melanotan II the chain is closed into a ring via a lactam bridge between aspartic acid and lysine. In addition, methionine has been replaced by norleucine, which does not oxidise, and phenylalanine by its mirror-image form D-phenylalanine.
Together with the acetylated start and the amidated end, this makes the molecule more stable and more resistant to enzymatic breakdown than the original hormone.
What does the research examine?
Melanotan II is a non-selective agonist of the melanocortin receptors: it binds to MC1R, MC3R, MC4R and MC5R. The literature focuses mainly on MC1R on melanocytes, the cells that produce pigment, and on the formation of eumelanin.
Binding to MC3R and MC4R in the central nervous system is also studied. That second line of research later led to the development of PT-141.
Melanotan II, Melanotan I and PT-141: the difference
Melanotan I (afamelanotide) is the linear predecessor of thirteen amino acids. It is registered in the EU as a medicine for the rare condition erythropoietic protoporphyria.
PT-141 (bremelanotide) has the same ring structure as melanotan II, but ends in an acid group instead of an amide and is regarded as a metabolite of melanotan II. Melanotan II itself is the shorter, cyclic and non-selective variant of the three.
Related products in our assortment are GHK-Cu, KPV and PT-141. How to dissolve the powder with bacteriostatic water is explained in our reconstitution and storage guide. The full range is listed under Skin, hair & cosmetic.
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Frequently Asked Questions
What is Melanotan II?
Melanotan II is a synthetic peptide of seven amino acids, derived from the body's own hormone α-MSH of the melanocortin family.
Is melanotan 2 the same as melanotan II?
Yes. Melanotan 2, MT-2 and MT-II are different spellings of the same peptide.
What is the difference between melanotan II and PT-141?
PT-141 has the same cyclic structure of seven amino acids, but ends in an acid group instead of an amide. It is regarded as a metabolite of melanotan II.
What is the research into Melanotan II about?
The research focuses on the melanocortin receptors. The literature describes the compound as an agonist of the melanocortin-1 receptor on melanocytes and studies the formation of eumelanin.
Why is Melanotan II called a cyclic peptide?
Because there is a ring closure between two of the seven amino acids. As a result part of the chain forms a closed ring rather than a straight line.
Is Melanotan II an approved medicine?
No. The substance is not registered as a medicine anywhere. What we supply is intended exclusively for laboratory research.
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